Metabo-Assist is a high-concentration, highly purified
polyphenolic blend that has been scientifically demonstrated
to make positive shifts in functional metabolic targets.
It provides multidimensional support to maintain blood
pressure levels already within the normal range, manage
weight, and increase satiety and appetite control. Metabo-Assist
provides a potent formula for those seeking to optimize their
metabolism and cardiovascular health.
Overview
Maintaining healthy blood pressure levels has become a primary
concern for many in the United States and across the globe.
Blood pressure fluctuations cause a variety of cardiovascular
challenges, and this is one of the most common cardiometabolic
challenges experienced. In the Framingham study, the risk of
having blood pressure challenges over a lifetime was 90%,
while it is estimated that the global burden will increase to
1.56 billion by 2025.1
While traditional therapies are available,
most are not well-tolerated, making diet and lifestyle changes,
such as whole food-based diets, increasing physical activity and
targeted nutrient support, the optimal way to maintain blood
pressure levels already within the normal range.2
There is abundant evidence that dietary factors play a central
role in determining cardiovascular risk driven by several
potential mechanisms.3
Among various factors determining
human health, dietary patterns such as the Mediterranean
diet or the DASH diet model have been demonstrated to play
a role in helping maintain vascular health and preserving
optimal blood pressure levels.4
A common feature of such
dietary patterns is the richness in plant-derived foods, which
are high in fiber and phytochemicals proven to be antioxidant
powerhouses. Polyphenols are a large group of plant
metabolites that exert a variety of key biological activities
including increasing satiety hormones (like GLP-1 [glucagonlike peptide-1]) and decreasing hunger hormones (like
ghrelin). In addition, targeted plant bioactives have also been
shown to stimulate 5’adenosine monophosphate-activated
protein kinase (AMPK), which has been shown to be a primary
activating mechanism for human metabolism. AMPK may
create such positive effects through its capability to modulate
energy homeostasis, total daily energy expenditure, lipid
oxidation and metabolism.5
HiPhenolic provides a targeted blend of key polyphenols that
maintain energy and metabolic efficiency, maintain normal
blood pressure levels, and support overall cardiometabolic
function.
Metabolaid®
(Hibiscus and Lemon Verbena Extract)
Lemon verbena (Lippia citriodora) has been used as a food
spice, cosmetic, and in traditional formulations in South
America and Southern Europe. Hibiscus flower (Hibiscus
sabdariffa L.) is used in traditional Chinese formulations in
the manner of a tea to help maintain normal blood pressure
levels and normal inflammatory balance. Metabolaid® is a
combination of the plant polyphenols in lemon verbena and
hibiscus flower extracts. These extracts have been shown to
work synergistically on the activation of the energy sensor
AMPK and promote optimal metabolic efficiency through the
modulation of fat metabolism.
• Multidimensional Support for Optimal Blood Pressure Levels
• Helps Enhance Metabolic Activity and Efficiency
• Aids in Supporting Optimal Weight and Reducing Cravings
• Supports Healthy Cardiometabolic Function
CLINICAL APPLICATIONS
CARDIOVASCULAR HEALTH
† These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.
In a 2018 double-blind, placebo-controlled and randomized
trial in 56 subjects with weight management challenges,
participants were given 500 mg of a combination of
polyphenolic extracts from Lippia citriodora and Hibiscus
sabdarifa L. for two months and showed significant
improvement in body weight, abdominal circumference, and
body fat percentage. Heart rate and systolic blood pressure
also were maintained within the normal range.6
In another
eight-week, randomized, double-blind, placebo-controlled
trial, 54 participants given the same extract showed an
improvement of anthropometric measurements, maintenance
of blood pressure within the normal range, and improved
heart rate. In addition, they experienced positive perception
of overall health status. This polyphenolic combination has
been shown to significantly increase metabolic function and
support healthy weight by decreasing appetite biomarkers.
This may help to avoid the undesired weight rebound typical
of calorie restriction diets.5
Green Coffee Bean Extract
Coffee is one of the most consumed drinks in the world. Green
coffee beans are the beans from the Coffea fruit that have not
yet been roasted. Coffee beans are naturally high in chlorogenic
acid, and roasting them reduces the chlorogenic acid content.
Chlorogenic acid, a polyphenol, is what holds the antioxidant
properties and increases the overall health benefits of coffee;7
therefore, the effects and benefits of coffee are maximized in
its natural and unroasted state. In addition, the green coffee
bean extract in Metabo-Assist has had the caffeine removed, so
the benefits of the polyphenols can be maximized.
A meta-analysis of nine randomized, controlled trials with
green coffee bean extract (GCBE) administered for four
weeks showed a benefit in maintaining blood pressure levels
already in the normal range—both systolic and diastolic.8
In
another systemic review and meta-analysis study consisting
of 637 participants, it was shown that green coffee bean
extract consumption can help maintain optimal lipid markers,
decrease body weight, and improve metabolism and glucose
disposal.9
Finally, in a randomized clinical trial, 43 subjects
consumed GCBE for eight weeks. After supplementation, all
indices of cardiovascular health showed benefits. Additionally,
waist circumference and appetite score of the individuals
supplemented with GCBE indicated a significant decline.10
Magnesium Citrate
Magnesium is a cofactor in more than 300 enzyme systems
that regulate diverse biochemical reactions in the body,
including protein synthesis, muscle and nerve function,
blood glucose control, and blood pressure regulation.11-13
Magnesium is required for energy creation, which involves
oxidative phosphorylation and glycolysis. It contributes to the
development of bone and is required for the synthesis of DNA,
RNA, and the antioxidant glutathione. Magnesium also plays
a role in the active transport of calcium and potassium ions
across cell membranes, a process that is important to nerve
impulse conduction, muscle contraction, and normal heart
rhythm.13 The role of magnesium as an enzyme cofactor for
activities that generate adenosine triphosphate (ATP) highlight
its significance for maintaining energy levels and metabolic
efficiency.
A meta-analysis of randomized, double-blind, placebo controlled studies on the effects of magnesium
supplementation on blood pressure showcased 34 trials
involving 2,028 participants who, while using magnesium
supplementation with a median duration of three months,
showed benefits in maintaining systolic and diastolic blood
pressure within the normal range for adults.14,15 Overall, oral
magnesium citrate supplementation has been shown to
maintain healthy blood pressure and blood sugar markers.15
Directions
2 capsules per day or as recommended by your health care
professional.
Does Not Contain
Gluten, corn, yeast, artificial colors or flavors.
Cautions
Do not consume this product if you are pregnant or nursing.
Consult your physician for further information.